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Lee Lab: Understanding Signal Transduction in hematopoiesis and neurogenesis


Lee, A. W., Mao, Y., Penninger, J. M. and Yu, S. (2011) "Gab2 promotes Colony Stimulating Factor-1 regulated macrophage expansion via alternative effectors at different stages of development” Mol. Cell. Biol. 31: 4563-81; ePub ahead of print September 19th, 2011, doi:10.1128/MCB.05706-11 abstract; selected as an article of significant interest click here

Lee, A. W. (2011) "The role of atypical protein kinase C in CSF-1 dependent Erk activation and proliferation in myeloid progenitors and macrophages" PLoS ONE 6: e25580, doi:10.1371/journal.pone.0025580 abstract

Yang P., Mao Y., Lee, A. W. and Kennedy, R. T. (2009) “Measurement of dissociation rate of biomolecular complexes using CE” Electrophoresis 30:457-64 abstract

Chen, Y., Blackwell, T.W., Chen, J., Gao, J., Menon, R., Lee, A. W.-M., and States, D. J. (2007) “Integration of genome and chromatin structure with gene expression profiles to predict c-Myc recognition site binding and function”, PLoS Computational Biology 3:e63 (doi:10.1371/journal.pcbi.0030063) abstract

Chen, J., Blackwell, T., Fermin, D., Menon, R., Gao, J., Lee, A. W. and States, D. J. (2007) “Evolutionarily conserved gene expression response profiles”, OMICS 11:96-122 abstract

Yang, P., Whelan, R. J., Mao, Y. W., Lee, A. W.-M., Carter-Su, C. and Kennedy, R. T. (2007) “Multiplexed Detection of Protein-Peptide Interaction and Inhibition Using Capillary Electrophoresis” Anal. Chem. 79:1690-1695 abstract

Lee, A. W. (senior author) and States, D. J. (2006) “Colony Stimulating Factor-1 requires PI3-kinase mediated glycolysis for proliferation and survival in myeloid cells” Cell Death Differ. 13:1900-1914 pdf

Mao, Y. W. and Lee, A. W. (2005) “A Novel Role for Gab2 in bFGF-mediated Cell Survival during Retinoic Acid-induced Neuronal Differentiation” J. Cell Biol., 170:305-16 pdf

Rohde, C. M., Schrum, J. and Lee, A. W. (2004) “A juxtamembrane domain tyrosine in the colony stimulating factor-1 receptor (CSF-1R) regulates ligand-induced kinase function and receptor degradation” J. Biol. Chem., 279:43448-43461 pdf

Lee, A. W. (senior author) and States, D. J. (2000) Guide to CD115 (CSF-1R) in Protein Reviews on the Web, Editor Stephen Shaw, Reviewer E. Richard Stanley

Lee, A. W.-M (senior author) and States, D. J. (2000) "Both Src-Dependent and Independent Mechanisms Mediate Phosphatidylinositol 3-Kinase Regulation of Colony-Stimulating Factor-1-activated MAP Kinases in Myeloid Progenitors" Mol. Cell. Biol. 20:6779-6798 pdf

Lee, A. W.-M. (senior author), Nambirajan, S. and Moffat, J. G. (1999) "CSF-1-activates MAPK-dependent and p53-independent pathways to induce growth arrest of hormone-dependent human breast cancer cells" Oncogene 18:7477-7494 pdf 

Lee, A. W.-M. (1999) "Synergistic Activation of Mitogen-Activated Protein Kinase by Cyclic AMP and Myeloid Growth Factors opposes Cyclic AMP's Growth-Inhibitory Effects", Blood 93: 537-553 abstract

Lee, A. W.-M. and Nienhuis, A. W. (1992) "Functional Dissection of Structural Domains in the Receptor for Colony-Stimulating Factor 1" J. Biol. Chem. 267:16472-16483. abstract

Redner, R., Lee, A. W.-M., Osawa, G. and Nienhuis, A. W. (1992) "Variable Pattern of Jun and Fos Gene Expression in Different Hematopoietic Cell Lines during Interleukin-3 induced entry into the Cell Cycle" Oncogene 7:43-50 abstract

Lee, A. W.-M. (1992) "Signal Transduction by the Colony-stimulating factor-1 receptor;  a comparison to other Receptor Tyrosine Kinases" in Current Topics in Cellular Regulation  32:73-181

Lee, A. W.-M. and Nienhuis, A. W. (1990) "Mechanism of Kinase Activation in the Receptor for Colony-stimulating factor-1" Proc. Natl. Acad. Sci. USA 87:7270-7274. pdf


Contact Information:
Angel W. Lee, M.D., Ph.D.